› 7td9

X-ray diffraction
1.61Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription activator BRG1 Chains: AAA, BBB, CCC
Molecule details ›
Chains: AAA, BBB, CCC
Length: 130 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51532 (Residues: 1448-1575; Coverage: 8%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand GJN 3 x GJN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P65
Unit cell:
a: 90.26Å b: 90.26Å c: 96.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.242
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy.
Zhang et al. (2022)
2 other articles

1 mention without citation

The pyridazine heterocycle in molecular recognition and drug discovery.
Meanwell NA. (2023)

PDB-REDO

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