› 7tdj

Electron Microscopy
3.7Å resolution

Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in closed-inactivated conformation class 1(Dataset-A)

Released:
DOI: 10.2210/pdb7tdj/pdb
PDB entry 7tdj coloured by chain, front view.
PDB entry 7tdj coloured by chain, side view.
PDB entry 7tdj coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Ca2+ inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM.
Nayak AR, Samsó M
OpenAccess logo Elife 11 (2022)
PMID: 35257661
Related structures: EMD-25831

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 533.66 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-5037; Coverage: 100%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ACP 4 x ACP
Ligand ZN 4 x ZN
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-25831

Quick links

Citations

1 review citation

Three-dimensional perspective on ryanodine receptor mutations causing skeletal and cardiac muscle-related diseases.
Iyer et al. (2023)
3 other articles

1 mention without citation

Ca2+ inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM.
Nayak et al. (2022)