7teq

Electron Microscopy
7.51Å resolution

Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 active conformation

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-211108 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 862 amino acids
Theoretical weight: 96.94 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35439 (Residues: 1-190, 191-838; Coverage: 89%)
  • Best match: P35439-2 (Residues: 1-859)
Gene names: Grin1, Nmdar1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 883 amino acids
Theoretical weight: 98.8 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00960 (Residues: 27-852; Coverage: 57%)
Gene name: Grin2b
Sequence domains:
Fab5 heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus
Fab5 light chain Chains: L, N
Molecule details ›
Chains: L, N
Length: 209 amino acids
Theoretical weight: 23.12 KDa
Source organism: Mus musculus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.51Å
Relevant EMDB volumes: EMD-25849
Expression system: Spodoptera frugiperda