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Electron Microscopy
4Å resolution

Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-212186 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (9 distinct):
Envelope glycoprotein gp160 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Anti-HIV-1 CD4bs antibody Fab Ab1303 - Heavy chain Chains: H, I, P
Molecule details ›
Chains: H, I, P
Length: 235 amino acids
Theoretical weight: 25.34 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
CD4 binding site antibody Fab Ab1303 - light chain Chains: J, L, Q
Transmembrane protein gp41 Chains: X, Y, Z

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-25877
Expression systems:
  • Cricetulus griseus
  • Homo sapiens