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Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs

Electron Microscopy
3.2Å resolution
PDB entry 7tj8 coloured by chain, front view.
PDB entry 7tj8 coloured by chain, side view.
PDB entry 7tj8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sodium channel
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Multimeric state: hetero dimer
Accessible surface area: 65918.51 Å2
Buried surface area: 14050.7 Å2
Dissociation area: 1,983.71 Å2
Dissociation energy (ΔGdiss): 17.65 kcal/mol
Dissociation entropy (TΔSdiss): 14.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169523

Macromolecules

Sodium channel protein type 7 subunit alpha
Chain: A
Length: 1737 amino acids
Theoretical weight: 199.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01118 (Residues: 1-1682; Coverage: 100%)
Gene names: SCN6A, SCN7A
Pfam:
InterPro:
Sodium channel protein type 7 subunit alpha in PDB entry 7tj8, assembly 1, front view.
Sodium channel protein type 7 subunit alpha in PDB entry 7tj8, assembly 1, side view.
Sodium channel protein type 7 subunit alpha in PDB entry 7tj8, assembly 1, top view.
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Sodium channel regulatory subunit beta-3
Chain: B
Length: 215 amino acids
Theoretical weight: 24.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NY72 (Residues: 1-215; Coverage: 100%)
Gene names: KIAA1158, SCN3B
Pfam: Immunoglobulin V-set domain
InterPro:
Sodium channel subunit beta-3 in PDB entry 7tj8, assembly 1, front view.
Sodium channel subunit beta-3 in PDB entry 7tj8, assembly 1, side view.
Sodium channel subunit beta-3 in PDB entry 7tj8, assembly 1, top view.
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