› 7tn0

X-ray diffraction
2.85Å resolution

SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab

Released:
DOI: 10.2210/pdb7tn0/pdb
Model geometry
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PDB entry 7tn0 coloured by chain, front view.
PDB entry 7tn0 coloured by chain, side view.
PDB entry 7tn0 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.
McCallum M, Czudnochowski N, Rosen LE, Zepeda SK, Bowen JE, Walls AC, Hauser K, Joshi A, Stewart C, Dillen JR, Powell AE, Croll TI, Nix J, Virgin HW, Corti D, Snell G, Veesler D
OpenAccess logo Science 375 864-868 (2022)
PMID: 35076256

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-209666 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
S309 light chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 214 amino acids
Theoretical weight: 23.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S309 heavy chain Chains: B, C
Molecule details ›
Chains: B, C
Length: 230 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Processed angiotensin-converting enzyme 2 Chains: E, F
S304 Fab light chain Chains: G, N
S304 Fab heavy chain Chains: H, M
Spike protein S1 Chains: I, S

Ligands and Environments

4 bound ligands:
Ligand EDO 11 x EDO
Ligand CL 21 x CL
Ligand ZN 2 x ZN
Ligand NAG 11 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 78.28Å b: 183.65Å c: 194.55Å
α: 90° β: 95.98° γ: 90°
R-values:
R R work R free
0.232 0.23 0.268
Expression systems:
  • Homo sapiens
  • Cricetulus griseus

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Citations

53 review citations

The evolution of SARS-CoV-2.
Markov et al. (2023)
52 more

18 mentions without citation

Next-generation treatments: Immunotherapy and advanced therapies for COVID-19.
Arevalo-Romero et al. (2024)
17 more

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