› 7tnj

Electron Microscopy
4.02Å resolution

Complex NNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)

Released:
DOI: 10.2210/pdb7tnj/pdb
PDB entry 7tnj coloured by chain, front view.
PDB entry 7tnj coloured by chain, side view.
PDB entry 7tnj coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Opening of glutamate receptor channel to subconductance levels.
Yelshanskaya MV, Patel DS, Kottke CM, Kurnikova MG, Sobolevsky AI
OpenAccess logo Nature 605 172-178 (2022)
PMID: 35444281
Related structures: EMD-26011

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2; Voltage-dependent calcium channel gamma-3 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1033 amino acids
Theoretical weight: 115.44 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: Q8VHX0 (Residues: 5-171, 172-207; Coverage: 64%)
Gene names: Cacng3, GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CYZ 4 x CYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.02Å
Relevant EMDB volumes: EMD-26011
Expression system: Homo sapiens

Quick links

Citations

8 review citations

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications.
Feng et al. (2023)
7 more