› 7toe

Electron Microscopy
3Å resolution

Structure of G6PD-WT tetramer with no symmetry imposed

Released:
DOI: 10.2210/pdb7toe/pdb
PDB entry 7toe coloured by chain, front view.
PDB entry 7toe coloured by chain, side view.
PDB entry 7toe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity.
Wei X, Kixmoeller K, Baltrusaitis E, Yang X, Marmorstein R
OpenAccess logo Proc Natl Acad Sci U S A 119 e2119695119 (2022)
PMID: 35858355
Related structures: EMD-26030

Function and Biology Details

Reaction catalysed: 
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate 1-dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 523 amino acids
Theoretical weight: 60.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11413 (Residues: 1-515; Coverage: 100%)
Gene name: G6PD
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-26030
Expression system: Escherichia coli

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Citations

1 review citation

The evolution of small molecule enzyme activators.
Dow et al. (2023)
5 other articles