› 7tot

X-ray diffraction
1.8Å resolution

Crystal Structure of pantothenate synthetase from Bartonella henselae

Released:
DOI: 10.2210/pdb7tot/pdb
PDB entry 7tot coloured by chain, front view.
PDB entry 7tot coloured by chain, side view.
PDB entry 7tot coloured by chain, top view.
Source organism: Bartonella henselae str. Houston-1
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.36 KDa
Source organism: Bartonella henselae str. Houston-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6G456 (Residues: 1-284; Coverage: 100%)
Gene names: BH05120, panC
Sequence domains: Pantoate-beta-alanine ligase

Ligands and Environments

3 bound ligands:
Ligand MPD 4 x MPD
Ligand NO3 7 x NO3
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 45.82Å b: 51.26Å c: 78.65Å
α: 108.9° β: 99.37° γ: 90.6°
R-values:
R R work R free
0.18 0.179 0.216
Expression system: Escherichia coli BL21(DE3)

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