› 7tti

Electron Microscopy
3.5Å resolution

Human KCC1 bound with VU0463271 In an outward-open state

Released:
DOI: 10.2210/pdb7tti/pdb
PDB entry 7tti coloured by chain, front view.
PDB entry 7tti coloured by chain, side view.
PDB entry 7tti coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Zhao Y, Shen J, Wang Q, Ruiz Munevar MJ, Vidossich P, De Vivo M, Zhou M, Cao E
OpenAccess logo Proc Natl Acad Sci U S A 119 e2109083119 (2022)
PMID: 35759661
Related structures: EMD-26116

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 12 member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1085 amino acids
Theoretical weight: 120.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UP95 (Residues: 1-1085; Coverage: 100%)
Gene names: KCC1, SLC12A4
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Ligand NAG 8 x NAG
1 bound ligand:
Ligand JUX 2 x JUX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-26116
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Structural Pharmacology of Cation-Chloride Cotransporters.
Zhao et al. (2022)
1 more

1 mention without citation

Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Fan et al. (2023)