› 7tuj

Solution NMR

NMR solution structure of the phosphorylated MUS81-binding region from human SLX4

Released:
DOI: 10.2210/pdb7tuj/pdb
PDB entry 7tuj coloured by chain, ensemble of 20 models, front view.
PDB entry 7tuj coloured by chain, ensemble of 20 models, side view.
PDB entry 7tuj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease.
Payliss BJ, Tse YWE, Reichheld SE, Lemak A, Yun HY, Houliston S, Patel A, Arrowsmith CH, Sharpe S, Wyatt HDM
Cell Rep 41 111537 (2022)
PMID: 36288699

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184925 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Structure-specific endonuclease subunit SLX4 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IY92 (Residues: 1528-1613; Coverage: 5%)
Gene names: BTBD12, KIAA1784, KIAA1987, SLX4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 3 x TPO

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The molecular basis for cellular function of intrinsically disordered protein regions.
Holehouse et al. (2023)
1 more