› 7tv7

Solution NMR

Heterogeneous-backbone proteomimetic analogue of the disulfide-rich venom peptide lasiocepsin: beta-3-Lys modified loop

Released:
DOI: 10.2210/pdb7tv7/pdb
PDB entry 7tv7 coloured by chain, ensemble of 10 models, front view.
PDB entry 7tv7 coloured by chain, ensemble of 10 models, side view.
PDB entry 7tv7 coloured by chain, ensemble of 10 models, top view.
Source organism: Lasioglossum laticeps
Primary publication:
Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold.
Cabalteja CC, Lin Q, Harmon TW, Rao SR, Di YP, Horne WS
ACS Chem Biol 17 987-997 (2022)
PMID: 35290019

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lasiocepsin Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 2.94 KDa
Source organism: Lasioglossum laticeps
Expression system: Not provided
UniProt:
  • Canonical: W5IDB3 (Residues: 1-27; Coverage: 100%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand B3K 3 x B3K

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
Yu et al. (2023)

1 mention without citation

Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold.
Cabalteja et al. (2022)