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Electron Microscopy
3.51Å resolution

Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-144657 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 1247 amino acids
Theoretical weight: 138.24 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
DARPin FSR22 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 225 amino acids
Theoretical weight: 23.84 KDa
Source organism: Escherichia phage EcSzw-2
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-26200
Expression systems:
  • Homo sapiens
  • Not provided