› 7tz2

X-ray diffraction
2.55Å resolution

Structure of human Fibrinogen-like protein 1

Released:
DOI: 10.2210/pdb7tz2/pdb
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PDB entry 7tz2 coloured by chain, front view.
PDB entry 7tz2 coloured by chain, side view.
PDB entry 7tz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
Ming Q, Celias DP, Wu C, Cole AR, Singh S, Mason C, Dong S, Tran TH, Amarasinghe GK, Ruffell B, Luca VC
Nat Immunol (2022)
PMID: 35761082

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170696 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrinogen-like protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 233 amino acids
Theoretical weight: 27.31 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q08830 (Residues: 74-306; Coverage: 80%)
Gene names: FGL1, HFREP1
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Unit cell:
a: 45.277Å b: 110.893Å c: 148.888Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.234
Expression system: Trichoplusia ni

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Citations

8 review citations

LAG-3 as the third checkpoint inhibitor.
Aggarwal et al. (2023)
7 more

1 mention without citation

The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy.
Mariuzza et al. (2024)

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