› 7u16

Electron Microscopy
2.7Å resolution

TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).

Released:
DOI: 10.2210/pdb7u16/pdb
PDB entry 7u16 coloured by chain, front view.
PDB entry 7u16 coloured by chain, side view.
PDB entry 7u16 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson DW, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
Cell 185 1346-1355.e15 (2022)
PMID: 35247328
Related structures: EMD-26279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein 106B Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 135 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NUM4 (Residues: 120-254; Coverage: 49%)
Gene name: TMEM106B
Sequence domains: TM106 protein C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-26279
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
6 more

1 mention without citation

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease.
Perneel et al. (2022)