› 7u1q

Electron Microscopy
3.9Å resolution

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation

Released:
DOI: 10.2210/pdb7u1q/pdb
PDB entry 7u1q coloured by chain, front view.
PDB entry 7u1q coloured by chain, side view.
PDB entry 7u1q coloured by chain, top view.
Source organisms:
Primary publication:
Ligand-mediated structural dynamics of a mammalian pancreatic KATP channel.
Woo Sung M, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol 167789 (2022)
PMID: 35964676
Related structures: EMD-26303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-550270 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 390 amino acids
Theoretical weight: 43.66 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
UniProt:
  • Canonical: P70673 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Sequence domains:
ATP-binding cassette sub-family C member 8 Chain: E
Molecule details ›
Chain: E
Length: 1582 amino acids
Theoretical weight: 177.33 KDa
Source organism: Cricetus cricetus
Expression system: Rattus norvegicus
UniProt:
  • Canonical: Q09427 (Residues: 1-1582; Coverage: 100%)
Gene names: ABCC8, SUR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand ATP 5 x ATP
Ligand K 1 x K
Ligand P5S 6 x P5S
Ligand POV 5 x POV
Ligand PTY 5 x PTY
Ligand BJX 1 x BJX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-26303
Expression system: Rattus norvegicus

Quick links

Citations

3 review citations

Mechanistic insights on KATP channel regulation from cryo-EM structures.
Driggers et al. (2023)
2 more

1 mention without citation

Ligand-mediated Structural Dynamics of a Mammalian Pancreatic KATP Channel.
Sung et al. (2022)