› 7u2o

Electron Microscopy
3.1Å resolution

A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-Expanded-open state

Released:
DOI: 10.2210/pdb7u2o/pdb
PDB entry 7u2o coloured by chain, front view.
PDB entry 7u2o coloured by chain, side view.
PDB entry 7u2o coloured by chain, top view.
Source organism: Danio rerio
Entry authors: Zhu H, Gouaux E
Related structures: EMD-26317

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycine receptor subunit alphaZ1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 436 amino acids
Theoretical weight: 49.82 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O93430 (Residues: 1-436; Coverage: 98%)
Gene name: glra1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 10 x NAG
Ligand BMA 5 x BMA
1 bound ligand:
Ligand L2L 5 x L2L
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-26317
Expression system: Spodoptera frugiperda

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