› › Structure analysis

Human V-ATPase in state 2 with SidK and mEAK-7

Electron Microscopy
3.6Å resolution
PDB entry 7u4t coloured by chain, front view.
PDB entry 7u4t coloured by chain, side view.
PDB entry 7u4t coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 36-mer (preferred)
Entry contents: 18 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vacuolar proton translocating ATPase complex, ATP6V0A1 variant
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Multimeric state: hetero 36-mer
Accessible surface area: 356325.1 Å2
Buried surface area: 136159.26 Å2
Dissociation area: 1,177.95 Å2
Dissociation energy (ΔGdiss): -3.77 kcal/mol
Dissociation entropy (TΔSdiss): 14.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127432

Macromolecules

V-type proton ATPase 116 kDa subunit a 1
Chain: R
Length: 837 amino acids
Theoretical weight: 96.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q93050 (Residues: 1-837; Coverage: 100%)
Gene names: ATP6N1, ATP6N1A, ATP6V0A1, VPP1
Pfam: V-type ATPase 116kDa subunit family
InterPro:
V-type proton ATPase 116 kDa subunit a 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase 116 kDa subunit a 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase 116 kDa subunit a 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q93050  
1837100200300400500600700800
 
200400600800MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE
UniProt
Q93050
Chains
Domains
Ligand binding sites
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit C 1
Chain: O
Length: 382 amino acids
Theoretical weight: 44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P21283 (Residues: 1-382; Coverage: 100%)
Gene names: ATP6C, ATP6D, ATP6V1C1, VATC
Pfam: V-ATPase subunit C
InterPro:
V-type proton ATPase subunit C 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit C 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit C 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P21283  
138250100150200250300350
 
100200300MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
UniProt
P21283
Chains
Domains
Sequence conservation
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V-type proton ATPase subunit E 1
Chains: H, I, J
Length: 226 amino acids
Theoretical weight: 26.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36543 (Residues: 1-226; Coverage: 100%)
Gene names: ATP6E, ATP6E2, ATP6V1E1
Pfam: ATP synthase (E/31 kDa) subunit
InterPro:
V-type proton ATPase subunit E 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit E 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit E 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P36543  
122620406080100120140160180200220
 
100200MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
UniProt
P36543
Chains
Domains
Interaction interfaces
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V-type proton ATPase subunit G 1
Chains: K, L, M
Length: 118 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75348 (Residues: 1-118; Coverage: 100%)
Gene names: ATP6G, ATP6G1, ATP6J, ATP6V1G1
Pfam: Vacuolar (H+)-ATPase G subunit
InterPro: Vacuolar (H+)-ATPase G subunit
V-type proton ATPase subunit G 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit G 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit G 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O75348  
1118102030405060708090100110
 
50100MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING
UniProt
O75348
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V-type proton ATPase subunit e 1
Chain: S
Length: 81 amino acids
Theoretical weight: 9.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15342 (Residues: 1-81; Coverage: 100%)
Gene names: ATP6H, ATP6V0E, ATP6V0E1
Pfam: ATP synthase subunit H
InterPro:
V-type proton ATPase subunit e 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit e 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit e 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O15342  
1811020304050607080
 
20406080MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
UniProt
O15342
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Domains
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Ribonuclease kappa
Chain: T
Length: 137 amino acids
Theoretical weight: 15.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P5S7 (Residues: 1-137; Coverage: 100%)
Gene name: RNASEK
InterPro: Ribonuclease kappa
Ribonuclease kappa in PDB entry 7u4t, assembly 1, front view.
Ribonuclease kappa in PDB entry 7u4t, assembly 1, side view.
Ribonuclease kappa in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6P5S7  
1137102030405060708090100110120130
 
50100MGWLRPGPRPLCPPARASWAFSHRFPSPLAPRRSPTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR
UniProt
Q6P5S7
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Sequence conservation
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V-type proton ATPase subunit S1
Chain: U
Length: 470 amino acids
Theoretical weight: 52.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15904 (Residues: 1-470; Coverage: 100%)
Gene names: ATP6AP1, ATP6IP1, ATP6S1, VATPS1, XAP3
Pfam:
InterPro:
V-type proton ATPase subunit S1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit S1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit S1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q15904  
147050100150200250300350400450
 
200400MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPAADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQVTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCASFFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
UniProt
Q15904
Chains
Domains
Ligand binding sites
Interaction interfaces
Sequence conservation
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Renin receptor
Chain: V
Length: 350 amino acids
Theoretical weight: 39.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75787 (Residues: 1-350; Coverage: 100%)
Gene names: ATP6AP2, ATP6IP2, CAPER, ELDF10, HT028, MSTP009, PSEC0072
Pfam: Renin receptor-like protein
InterPro: Renin receptor-like
Renin receptor in PDB entry 7u4t, assembly 1, front view.
Renin receptor in PDB entry 7u4t, assembly 1, side view.
Renin receptor in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O75787  
135050100150200250300350
 
100200300MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD
UniProt
O75787
PRO_0000447864
PRO_0000447865
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase 21 kDa proteolipid subunit c''
Chain: 0
Length: 205 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99437 (Residues: 1-205; Coverage: 100%)
Gene names: ATP6F, ATP6V0B
Pfam: ATP synthase subunit C
InterPro:
V-type proton ATPase 21 kDa proteolipid subunit c'' in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase 21 kDa proteolipid subunit c'' in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase 21 kDa proteolipid subunit c'' in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q99437  
120520406080100120140160180200
 
50100150200MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
UniProt
Q99437
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase 16 kDa proteolipid subunit c
Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9
Length: 155 amino acids
Theoretical weight: 15.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27449 (Residues: 1-155; Coverage: 100%)
Gene names: ATP6C, ATP6L, ATP6V0C, ATPL
Pfam: ATP synthase subunit C
InterPro:
V-type proton ATPase 16 kDa proteolipid subunit c in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase 16 kDa proteolipid subunit c in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase 16 kDa proteolipid subunit c in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P27449  
115520406080100120140
 
50100150MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
UniProt
P27449
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit d 1
Chain: Q
Length: 351 amino acids
Theoretical weight: 40.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61421 (Residues: 1-351; Coverage: 100%)
Gene names: ATP6D, ATP6V0D1, VPATPD
Pfam: ATP synthase (C/AC39) subunit
InterPro:
V-type proton ATPase subunit d 1 in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit d 1 in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit d 1 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61421  
135150100150200250300350
 
100200300MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
UniProt
P61421
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase catalytic subunit A
Chains: A, B, C
Length: 617 amino acids
Theoretical weight: 68.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P38606 (Residues: 1-617; Coverage: 100%)
Gene names: ATP6A1, ATP6V1A, ATP6V1A1, VPP2
Pfam:
InterPro:
V-type proton ATPase catalytic subunit A in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase catalytic subunit A in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase catalytic subunit A in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P38606  
161750100150200250300350400450500550600
 
200400600MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED
UniProt
P38606
Chains
Domains
Ligand binding sites
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit B, brain isoform
Chains: D, E, F
Length: 511 amino acids
Theoretical weight: 56.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P21281 (Residues: 1-511; Coverage: 100%)
Gene names: ATP6B2, ATP6V1B2, VPP3
Pfam:
InterPro:
V-type proton ATPase subunit B, brain isoform in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit B, brain isoform in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit B, brain isoform in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P21281  
151150100150200250300350400450500
 
200400MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
UniProt
P21281
Chains
Domains
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Type IV secretion protein Dot
Chains: X, Y, Z
Length: 573 amino acids
Theoretical weight: 65.51 KDa
Source organism: Legionella pneumophila
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5ZWW6 (Residues: 1-573; Coverage: 100%)
Gene name: lpg0968
Type IV secretion protein Dot in PDB entry 7u4t, assembly 1, front view.
Type IV secretion protein Dot in PDB entry 7u4t, assembly 1, side view.
Type IV secretion protein Dot in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q5ZWW6  
157350100150200250300350400450500550
 
200400MSFIKVGIKMGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASKSGKCPNDLDALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYLKNAAPTPKNNFLRAMTSVLQMQIAQYGITEDNEGINQLFKLGLHLLAMANEKIDEQYHLFKGYVKDQPEESPFEGILPAEDQKILVKTMIDYAMPKLSSKVLQDKLSALSSSDVLTKTLLDSIDRIVKENEKLNALSKVKLGKFGLDIREIEVIYSQALKISPQDALQYTAQQCDAQLLSMAFPDSQNYIIESISNKKVKTIAELIHSKEFIYQIIKTEVFKQVDPNEKIRLQAATELYQLLGRIMDKQINLFTKMNLEQINEYIQTKTKAILDKIPERVELLTFMGFEIPTFKGIETLMTDISHSQDNETLAIAQEFYTNIKNAKNQLLGDKLIEDITPQDVEKFFNQCSQYGSEAAEKLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTLGSLQKVQEESLSL
UniProt
Q5ZWW6
Chains
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit D
Chain: G
Length: 247 amino acids
Theoretical weight: 28.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y5K8 (Residues: 1-247; Coverage: 100%)
Gene names: ATP6M, ATP6V1D, VATD
Pfam: ATP synthase subunit D
InterPro: ATPase, V1 complex, subunit D
V-type proton ATPase subunit D in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit D in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit D in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9Y5K8  
124720406080100120140160180200220240
 
100200MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE
UniProt
Q9Y5K8
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit F
Chain: N
Length: 119 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16864 (Residues: 1-119; Coverage: 100%)
Gene names: ATP6S14, ATP6V1F, VATF
Pfam: ATP synthase (F/14-kDa) subunit
InterPro:
V-type proton ATPase subunit F in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit F in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit F in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q16864  
1119102030405060708090100110
 
50100MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR
UniProt
Q16864
Chains
Domains
Interaction interfaces
Sequence conservation
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V-type proton ATPase subunit H
Chain: P
Length: 483 amino acids
Theoretical weight: 55.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UI12 (Residues: 1-483; Coverage: 100%)
Gene names: ATP6V1H, CGI-11
Pfam:
InterPro:
V-type proton ATPase subunit H in PDB entry 7u4t, assembly 1, front view.
V-type proton ATPase subunit H in PDB entry 7u4t, assembly 1, side view.
V-type proton ATPase subunit H in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9UI12  
148350100150200250300350400450
 
200400MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS
UniProt
Q9UI12
Chains
Domains
Sequence conservation
Molecule details ›

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MTOR-associated protein MEAK7
Chain: W
Length: 456 amino acids
Theoretical weight: 51.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P9B6 (Residues: 1-456; Coverage: 100%)
Gene names: KIAA1609, MEAK7, TLDC1
Pfam: TLD
InterPro: TLDc domain
MTOR-associated protein MEAK7 in PDB entry 7u4t, assembly 1, front view.
MTOR-associated protein MEAK7 in PDB entry 7u4t, assembly 1, side view.
MTOR-associated protein MEAK7 in PDB entry 7u4t, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6P9B6  
145650100150200250300350400450
 
200400MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALQNHVGEALPPEMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGRGFESILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDVDFGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWAVGDPSEEQLAKGNKSILDADPEAQALLEISGHSRHSEGLREVPDDE
UniProt
Q6P9B6
Chains
Domains
Interaction interfaces
Sequence conservation
Molecule details ›

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