› 7u5b

X-ray diffraction
2.37Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-578784 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
anti-KLK5 Fab Heavy Chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 224 amino acids
Theoretical weight: 23.66 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus
anti-KLK5 Fab Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 217 amino acids
Theoretical weight: 23.36 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus
Kallikrein-5 Chains: I, J
Molecule details ›
Chains: I, J
Length: 227 amino acids
Theoretical weight: 25.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni

Ligands and Environments

1 bound ligand:
Ligand SO4 15 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: F222
Unit cell:
a: 83.686Å b: 283.624Å c: 295.575Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.27
Expression systems:
  • Cricetulus griseus
  • Trichoplusia ni

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Citations

1 review citation

Genetic and Immunological Pathogenesis of Atopic Dermatitis.
Schuler et al. (2024)
7 other articles