7u5o

X-ray diffraction
3.45Å resolution

CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-140689 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibin beta B chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 115 amino acids
Theoretical weight: 12.83 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P09529 (Residues: 293-407; Coverage: 30%)
Gene name: INHBB
Sequence domains: Transforming growth factor beta like domain
Bone morphogenetic protein receptor type-2 Chains: E, F, G
Molecule details ›
Chains: E, F, G
Length: 111 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q13873 (Residues: 27-137; Coverage: 11%)
Gene names: BMPR2, PPH1
Sequence domains: Activin types I and II receptor domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2
Unit cell:
a: 80.96Å b: 115.46Å c: 110.16Å
α: 90° β: 100.92° γ: 90°
R-values:
R R work R free
0.238 0.236 0.284
Expression system: Cricetulus griseus