Function and Biology

Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and dGTP

Source organisms:
Biochemical function: cobalt ion binding
Biological process: DNA replication
Cellular component: not assigned

EC 3.1.5.1: dGTPase

Reaction catalysed:
dGTP + H(2)O = deoxyguanosine + triphosphate
Systematic name:
dGTP triphosphohydrolase
Alternative Name(s):
  • Deoxy-GTPase
  • Deoxyguanosine 5-triphosphate triphosphohydrolase
  • Deoxyguanosine triphosphatase
  • Deoxyguanosine triphosphate triphosphohydrolase
  • Deoxyguanosinetriphosphate triphosphohydrolase

Sequence families

Pfam Protein families (Pfam)
PF10922
Domain description: Bacteriophage T7-like, gene 1.2
Occurring in:
  1. Inhibitor of dGTPase
The deposited structure of PDB entry 7u66 contains 6 copies of Pfam domain PF10922 (Bacteriophage T7-like, gene 1.2) in Inhibitor of dGTPase. Showing 1 copy in chain B [auth G].

PF01966
Domain description: HD domain
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
The deposited structure of PDB entry 7u66 contains 6 copies of Pfam domain PF01966 (HD domain) in Deoxyguanosinetriphosphate triphosphohydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006674
Domain description: HD domain
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
IPR003607
Domain description: HD/PDEase domain
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
IPR020147
Domain description: Inhibitor of dGTPase, bacteriophage T7-like
Occurring in:
  1. Inhibitor of dGTPase
IPR026875
Domain description: Phosphohydrolase-associated domain
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
IPR023293
Domain description: Deoxyguanosinetriphosphate triphosphohydrolase, central domain superfamily
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
IPR006261
Domain description: dGTP triphosphohydrolase
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase
IPR020779
Domain description: dNTP triphosphohydrolase, type 1
Occurring in:
  1. Deoxyguanosinetriphosphate triphosphohydrolase