› 7u9g

Electron Microscopy
3.39Å resolution

Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122

Released:
DOI: 10.2210/pdb7u9g/pdb
PDB entry 7u9g coloured by chain, front view.
PDB entry 7u9g coloured by chain, side view.
PDB entry 7u9g coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Callaway HM, Zyla D, Larrous F, de Melo GD, Hastie KM, Avalos RD, Agarwal A, Corti D, Bourhy H, Saphire EO
OpenAccess logo Sci Adv 8 eabp9151 (2022)
PMID: 35714192
Related structures: EMD-26397

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279556 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Rabies virus strain Pasteur vaccin
Expression system: Homo sapiens
UniProt:
  • Canonical: P08667 (Residues: 1-439; Coverage: 83%)
Gene name: G
Sequence domains: Rhabdovirus spike glycoprotein
RVA122 Fab Light Chain Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 217 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
RVA122 Fab Heavy Chain Chains: G, H, I

Ligands and Environments

1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.39Å
Relevant EMDB volumes: EMD-26397
Expression systems:
  • Homo sapiens
  • Drosophila melanogaster

Quick links

Citations

3 review citations

α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain.
Shelukhina et al. (2023)
2 more

5 mentions without citation

Interactions between the rabies virus and nicotinic acetylcholine receptors: A potential role in rabies virus induced behavior modifications.
Lian et al. (2022)
4 more