7ua5

Electron Microscopy
2.83Å resolution

Structure of dephosphorylated human RyR2 in the closed state

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-159297 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ryanodine receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 4967 amino acids
Theoretical weight: 565.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92736 (Residues: 1-4967; Coverage: 100%)
  • Best match: Q92736-2 (Residues: 1-4975)
Gene name: RYR2
Sequence domains:
Peptidyl-prolyl cis-trans isomerase FKBP1B Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.83Å
Relevant EMDB volumes: EMD-26415
Expression systems:
  • Homo sapiens
  • Escherichia coli