7uae

Electron Microscopy
2.6Å resolution

Human meprin alpha (active state)

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Meprin A subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 587 amino acids
Theoretical weight: 67.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q16819 (Residues: 22-600; Coverage: 80%)
Gene name: MEP1A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-26422
Expression system: Drosophila melanogaster