› 7uey

X-ray diffraction
1.7Å resolution

PANK3 complex structure with compound PZ-4128

Released:
DOI: 10.2210/pdb7uey/pdb
PDB entry 7uey coloured by chain, front view.
PDB entry 7uey coloured by chain, side view.
PDB entry 7uey coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: White SW, Yun M, Lee RE

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 380 amino acids
Theoretical weight: 42.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H999 (Residues: 12-370; Coverage: 97%)
Gene name: PANK3
Sequence domains: Fumble

Ligands and Environments

4 bound ligands:
Ligand ANP 2 x ANP
Ligand N0R 1 x N0R
Ligand MG 2 x MG
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 98.545Å b: 98.545Å c: 68.939Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.168 0.188
Expression system: Escherichia coli

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