› 7ukl

Electron Microscopy
3.09Å resolution

Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein

Released:
DOI: 10.2210/pdb7ukl/pdb
PDB entry 7ukl coloured by chain, front view.
PDB entry 7ukl coloured by chain, side view.
PDB entry 7ukl coloured by chain, top view.
Source organisms:
Primary publication:
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.
Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD
Immunity (2023)
PMID: 37776849
Related structures: EMD-26583

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233273 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
12-16 Fab Light Chain Chains: L, N, Y
Molecule details ›
Chains: L, N, Y
Length: 108 amino acids
Theoretical weight: 11.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1273 amino acids
Theoretical weight: 141.21 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1273; Coverage: 100%)
Gene names: 2, S
Sequence domains:
12-16 Fab Heavy Chain Chains: H, M, X
Molecule details ›
Chains: H, M, X
Length: 132 amino acids
Theoretical weight: 14.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 48 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.09Å
Relevant EMDB volumes: EMD-26583
Expression system: Homo sapiens

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