› 7unl

Electron Microscopy
2.45Å resolution

Human TMEM175 in an open state

Released:
DOI: 10.2210/pdb7unl/pdb
PDB entry 7unl coloured by chain, front view.
PDB entry 7unl coloured by chain, side view.
PDB entry 7unl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175.
Oh S, Marinelli F, Zhou W, Lee J, Choi HJ, Kim M, Faraldo-Gómez JD, Hite RK
Elife 11 (2022)
PMID: 35608336
Related structures: EMD-26626

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endosomal/lysosomal proton channel TMEM175 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Sequence domains: Endosomal/lysosomal potassium channel TMEM175

Ligands and Environments

1 bound ligand:
Ligand K 8 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.45Å
Relevant EMDB volumes: EMD-26626
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease.
Tang et al. (2023)
5 other articles

1 mention without citation

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175.
Oh et al. (2022)