› 7urt

Electron Microscopy
2.39Å resolution

T=1 particle HIV-1 CA G60A/G61P/M66A

Released:
DOI: 10.2210/pdb7urt/pdb
PDB entry 7urt coloured by chain, front view.
PDB entry 7urt coloured by chain, side view.
PDB entry 7urt coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid.
Schirra RT, Dos Santos NFB, Zadrozny KK, Kucharska I, Ganser-Pornillos BK, Pornillos O
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 36759579
Related structures: EMD-26718

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-227136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.62 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand IHP 2 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.39Å
Relevant EMDB volumes: EMD-26718
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Highlights on the Development, Related Patents, and Prospects of Lenacapavir: The First-in-Class HIV-1 Capsid Inhibitor for the Treatment of Multi-Drug-Resistant HIV-1 Infection.
Dzinamarira et al. (2023)
1 more

1 mention without citation

A molecular switch modulates assembly and host factor binding of the HIV-1 capsid.
Schirra et al. (2023)