› 7usi

X-ray diffraction
2.5Å resolution

BRD2-BD1 in complex with MDP5

Released:
DOI: 10.2210/pdb7usi/pdb
Model geometry
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PDB entry 7usi coloured by chain, front view.
PDB entry 7usi coloured by chain, side view.
PDB entry 7usi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma.
Sethi B, Kumar V, Jayasinghe TD, Dong Y, Ronning DR, Zhong HA, Coulter DW, Mahato RI
J Control Release 354 80-90 (2023)
PMID: 36599397

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 114 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 73-183; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

7 bound ligands:
Ligand O6O 6 x O6O
Ligand PEG 7 x PEG
Ligand EDO 27 x EDO
Ligand DMS 8 x DMS
Ligand CL 6 x CL
Ligand NA 2 x NA
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 63.81Å b: 149.872Å c: 63.819Å
α: 90° β: 112.27° γ: 90°
R-values:
R R work R free
0.204 0.201 0.25
Expression system: Escherichia coli

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Citations

1 citations in other articles

Probing the Potential of Defense Response-Associated Genes for Predicting the Progression, Prognosis, and Immune Microenvironment of Osteosarcoma.
Huang et al. (2023)

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