› 7uuz

Electron Microscopy
3.2Å resolution

Structure of the sodium/iodide symporter (NIS) in complex with perrhenate and sodium

Released:
DOI: 10.2210/pdb7uuz/pdb
PDB entry 7uuz coloured by chain, front view.
PDB entry 7uuz coloured by chain, side view.
PDB entry 7uuz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural insights into the mechanism of the sodium/iodide symporter.
Ravera S, Nicola JP, Salazar-De Simone G, Sigworth FJ, Karakas E, Amzel LM, Bianchet MA, Carrasco N
Nature (2022)
PMID: 36517601
Related structures: EMD-26807

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563184 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/iodide cotransporter Chain: A
Molecule details ›
Chain: A
Length: 694 amino acids
Theoretical weight: 73.91 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63008 (Residues: 2-618; Coverage: 100%)
Gene names: Nis, Slc5a5
Sequence domains: Sodium:solute symporter family

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand REO 1 x REO
Ligand 3PH 1 x 3PH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-26807
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Selenium, Iodine and Iron-Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.
Köhrle J. (2023)
3 more

1 mention without citation

Structural insights into the mechanism of the sodium/iodide symporter.
Ravera et al. (2022)