› 7uvs

X-ray diffraction
2.06Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233329 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
LMIV230-02 Fab heavy chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 226 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LMIV230-02 Fab light chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 221 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Gametocyte surface protein P230 Chains: C, F
Molecule details ›
Chains: C, F
Length: 199 amino acids
Theoretical weight: 22.69 KDa
Source organism: Plasmodium falciparum
Expression system: Homo sapiens
UniProt:
  • Canonical: P68874 (Residues: 552-731; Coverage: 6%)
Gene names: PF230, PF3D7_0209000, PFS230, S230

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 92.36Å b: 132.47Å c: 125.07Å
α: 90° β: 102.348° γ: 90°
R-values:
R R work R free
0.175 0.174 0.215
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

A human antibody epitope map of the malaria vaccine antigen Pfs25.
Shukla et al. (2023)
1 more

1 mention without citation

Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Ivanochko et al. (2023)