7uwj

Electron Microscopy
3.2Å resolution

Structure of the homodimeric IL-25-IL-17RB binary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-190539 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-25 Chains: A, B
Molecule details ›
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H293 (Residues: 30-177; Coverage: 100%)
Gene names: IL17E, IL25, UNQ3120/PRO10272
Sequence domains: Interleukin-17
Interleukin-17 receptor B Chains: C, D
Molecule details ›
Chains: C, D
Length: 255 amino acids
Theoretical weight: 28.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NRM6 (Residues: 18-272; Coverage: 53%)
Gene names: CRL4, EVI27, IL17BR, IL17RB, UNQ2501/PRO19612
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-26833
Expression system: Homo sapiens