7uwm

Electron Microscopy
2.5Å resolution

Structure of the IL-17A-IL-17RA binary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-172507 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-17A Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 169 amino acids
Theoretical weight: 19.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16552 (Residues: 25-155; Coverage: 99%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Interleukin-17 receptor A Chains: C, F
Molecule details ›
Chains: C, F
Length: 272 amino acids
Theoretical weight: 31.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96F46 (Residues: 33-304; Coverage: 33%)
Gene names: IL17R, IL17RA
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-26836
Expression system: Homo sapiens