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Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: tRNA processing
Cellular component: nucleolus

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EC 4.6.1.16: tRNA-intron lyase

Reaction catalysed:
PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
Systematic name:
PretRNA lyase (intron-removing; cyclic-2',3'-phosphate-forming)
Alternative Name(s):
  • Splicing endonuclease
  • Transfer ribonucleate intron endoribonuclease
  • Transfer splicing endonuclease
  • tRNA splicing endonuclease
  • tRNATRPintron endonuclease

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01974
Domain description: tRNA intron endonuclease, catalytic C-terminal domain
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen34
  2. tRNA-splicing endonuclease subunit Sen2
The deposited structure of PDB entry 7uxa contains 1 copy of Pfam domain PF01974 (tRNA intron endonuclease, catalytic C-terminal domain) in tRNA-splicing endonuclease subunit Sen34. Showing 1 copy in chain A.
The deposited structure of PDB entry 7uxa contains 1 copy of Pfam domain PF01974 (tRNA intron endonuclease, catalytic C-terminal domain) in tRNA-splicing endonuclease subunit Sen2. Showing 1 copy in chain C.

PF12928
Domain description: tRNA-splicing endonuclease subunit sen54 N-term
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen54
The deposited structure of PDB entry 7uxa contains 1 copy of Pfam domain PF12928 (tRNA-splicing endonuclease subunit sen54 N-term) in tRNA-splicing endonuclease subunit Sen54. Showing 1 copy in chain D.

PF02778
Domain description: tRNA intron endonuclease, N-terminal domain
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen2
The deposited structure of PDB entry 7uxa contains 1 copy of Pfam domain PF02778 (tRNA intron endonuclease, N-terminal domain) in tRNA-splicing endonuclease subunit Sen2. Showing 1 copy in chain C.

PF09631
Domain description: Sen15 protein
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen15
The deposited structure of PDB entry 7uxa contains 1 copy of Pfam domain PF09631 (Sen15 protein) in tRNA-splicing endonuclease subunit Sen15. Showing 1 copy in chain B.

Rfam RNA family (Rfam)
RF00005
Domain description: tRNA
Occurring in:
  1. RNA (78-MER)
The deposited structure of PDB entry 7uxa contains 1 copy of Rfam domain RF00005 (tRNA) in RNA (78-MER). Showing 1 copy in chain E.

InterPro InterPro annotations
IPR006677
Domain description: tRNA intron endonuclease, catalytic domain-like
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen34
  2. tRNA-splicing endonuclease subunit Sen2
IPR036167
Domain description: tRNA intron endonuclease, catalytic domain-like superfamily
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen34
  2. tRNA-splicing endonuclease subunit Sen15
  3. tRNA-splicing endonuclease subunit Sen2
IPR011856
Domain description: tRNA endonuclease-like domain superfamily
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen34
  2. tRNA-splicing endonuclease subunit Sen15
  3. tRNA-splicing endonuclease subunit Sen2
IPR024336
Domain description: tRNA-splicing endonuclease, subunit Sen54, N-terminal
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen54
IPR024337
Domain description: tRNA-splicing endonuclease, subunit Sen54
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen54
IPR006678
Domain description: tRNA intron endonuclease, N-terminal
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen2
IPR016589
Domain description: tRNA-splicing endonuclease, SEN2 subunit
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen2
IPR006676
Domain description: tRNA-splicing endonuclease
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen2
IPR018593
Domain description: tRNA-splicing endonuclease subunit Sen15
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen15
IPR016690
Domain description: tRNA-splicing endonuclease, SEN34 subunit
Occurring in:
  1. tRNA-splicing endonuclease subunit Sen34

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