Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA-directed DNA polymerase, family B
- DNA primase large subunit, eukaryotic/archaeal
- DNA primase, small subunit, eukaryotic/archaeal
- DNA primase, large subunit, eukaryotic
- DNA primase, small subunit
- DNA polymerase alpha/delta/epsilon, subunit B
- DNA polymerase alpha, subunit B
- DNA polymerase family B, thumb domain
8 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-125283 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
DNA polymerase alpha subunit B
Molecule details ›
Chain: B
Length: 595 amino acids
Theoretical weight: 68.77 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 595 amino acids
Theoretical weight: 68.77 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
I7MAE1 (Residues: 1-595; Coverage: 100%)
Sequence domains:
DNA polymerase
Molecule details ›
Chain: A
Length: 1393 amino acids
Theoretical weight: 161.99 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 1393 amino acids
Theoretical weight: 161.99 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q23AJ0 (Residues: 1-1393; Coverage: 100%)
Sequence domains:
Eukaryotic-type DNA primase, large subunit
Molecule details ›
Chain: D
Length: 540 amino acids
Theoretical weight: 64.39 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Eukaryotic and archaeal DNA primase, large subunit
Length: 540 amino acids
Theoretical weight: 64.39 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q246C7 (Residues: 1-540; Coverage: 100%)
Sequence domains: Eukaryotic and archaeal DNA primase, large subunit
DNA primase
Molecule details ›
Chain: C
Length: 399 amino acids
Theoretical weight: 47.17 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: DNA primase small subunit
Length: 399 amino acids
Theoretical weight: 47.17 KDa
Source organism: Tetrahymena thermophila
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q24HY6 (Residues: 1-399; Coverage: 100%)
Sequence domains: DNA primase small subunit
