7v0p

Electron Microscopy
5.2Å resolution

Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106

Released:

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228424 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
p130 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 400 amino acids
Theoretical weight: 43.63 KDa
Source organism: Eastern equine encephalitis virus
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: A1YZ44 (Residues: 802-1201; Coverage: 32%)
Gene names: F782_44605gpSP, F782_44606gpSP, F782_44607gpSP, F782_44610gpSP, F782_44611gpSP, F782_44617gpSP, F782_44618gpSP, F782_44623gpSP, F782_44625gpSP, F782_44628gpSP, F782_44630gpSP, F782_44632gpSP, F782_44634gpSP, F782_44635gpSP, F782_44639gpSP, F782_44640gpSP, F782_44653gpSP, F782_44654gpSP, F782_44655gpSP, F782_44656gpSP, F782_44657gpSP, F782_44659gpSP, F782_44660gpSP, F782_44661gpSP, F782_44663gpSP, F782_44666gpSP, F782_44667gpSP, F782_44668gpSP, F782_44674gpSP, F782_44827gpSP, F782_44835gpSP, F782_44836gpSP, NC02_52201gpSP, NC02_52202gpSP, NC02_52203gpSP, NC02_52204gpSP, NC02_52205gpSP, NC02_52207gpSP, NC02_52208gpSP, NC02_52211gpSP, NC02_52214gpSP, NC02_52217gpSP, NC02_52218gpSP, NC02_52219gpSP, NC02_52230gpSP, NC02_52231gpSP, NC02_52256gpSP, NC02_52257gpSP, NC02_52258gpSP, NC02_52262gpSP, NC02_52263gpSP, NC02_52264gpSP, NC02_52265gpSP, NC02_52266gpSP, NC02_52267gpSP, NC02_52269gpSP, NC02_52272gpSP, NC02_52273gpSP, NC02_52274gpSP, NC02_52275gpSP, NC02_52277gpSP, NC02_52278gpSP, NC02_52279gpSP, NC02_52548gpSP, NC02_52549gpSP, NC02_52551gpSP, NC02_52553gpSP, NC02_52554gpSP, NC02_52555gpSP, NC02_52556gpSP, NC02_52557gpSP, NC02_52558gpSP, NC02_52559gpSP, NC02_52560gpSP, NC02_52563gpSP, NC02_52567gpSP, NC02_52570gpSP, NC02_52571gpSP, NC02_52572gpSP, NC02_52573gpSP, NC02_52574gpSP, NC02_52576gpSP, NC02_52577gpSP, NC02_52581gpSP, NC02_52582gpSP, NC02_52589gpSP, NC02_52590gpSP, NC02_52593gpSP, NC02_52595gpSP, NC02_52608gpSP, NC02_52609gpSP, NC02_52610gpSP, NC02_52611gpSP, NC02_52612gpSP, NC02_52613gpSP, NC02_52614gpSP, NC02_52616gpSP, NC02_52624gpSP, NC02_52626gpSP, NC02_52627gpSP, NC02_52628gpSP, NC02_52630gpSP, NC02_54689gpSP, NC02_54732gpSP, NC02_54738gpSP, NC02_54889gpSP, NC02_54891gpSP, NC02_54892gpSP, NC02_54893gpSP, NC02_54894gpSP, NC02_54895gpSP, NC02_54896gpSP, NC02_54897gpSP, NC02_54899gpSP, NC02_54900gpSP, NC02_54901gpSP, NC02_54903gpSP, NC02_54904gpSP, NC02_54908gpSP, NC02_54909gpSP, NC02_54911gpSP, NC02_54915gpSP, NC02_54919gpSP, NC02_54920gpSP, NC02_54921gpSP, NC02_54928gpSP, NC02_54931gpSP, NC02_54932gpSP, NC02_54933gpSP, NC02_54935gpSP, NC02_54936gpSP, NC02_54940gpSP, NC02_54942gpSP, NC02_54944gpSP, NC02_54948gpSP, NC02_54949gpSP, NC02_54951gpSP, NC02_54953gpSP, NC02_54956gpSP, NC02_54957gpSP, NC02_54959gpSP, NC02_54963gpSP, NC02_54965gpSP, NC02_54967gpSP, NC02_54970gpSP, NC02_54971gpSP, NC02_54975gpSP, NC02_54976gpSP, NC02_54977gpSP, SP
Sequence domains: Alphavirus E1 glycoprotein
IgG 106 Fab heavy chain Chains: E, G, I, K
Molecule details ›
Chains: E, G, I, K
Length: 229 amino acids
Theoretical weight: 19.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IgG 106 Fab light chain Chains: F, H, J, L
Molecule details ›
Chains: F, H, J, L
Length: 212 amino acids
Theoretical weight: 18.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
p130 Chains: a, b, c, d
Molecule details ›
Chains: a, b, c, d
Length: 342 amino acids
Theoretical weight: 38.32 KDa
Source organism: Eastern equine encephalitis virus
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: A1YZ44 (Residues: 325-666; Coverage: 28%)
Gene names: F782_44605gpSP, F782_44606gpSP, F782_44607gpSP, F782_44610gpSP, F782_44611gpSP, F782_44617gpSP, F782_44618gpSP, F782_44623gpSP, F782_44625gpSP, F782_44628gpSP, F782_44630gpSP, F782_44632gpSP, F782_44634gpSP, F782_44635gpSP, F782_44639gpSP, F782_44640gpSP, F782_44653gpSP, F782_44654gpSP, F782_44655gpSP, F782_44656gpSP, F782_44657gpSP, F782_44659gpSP, F782_44660gpSP, F782_44661gpSP, F782_44663gpSP, F782_44666gpSP, F782_44667gpSP, F782_44668gpSP, F782_44674gpSP, F782_44827gpSP, F782_44835gpSP, F782_44836gpSP, NC02_52201gpSP, NC02_52202gpSP, NC02_52203gpSP, NC02_52204gpSP, NC02_52205gpSP, NC02_52207gpSP, NC02_52208gpSP, NC02_52211gpSP, NC02_52214gpSP, NC02_52217gpSP, NC02_52218gpSP, NC02_52219gpSP, NC02_52230gpSP, NC02_52231gpSP, NC02_52256gpSP, NC02_52257gpSP, NC02_52258gpSP, NC02_52262gpSP, NC02_52263gpSP, NC02_52264gpSP, NC02_52265gpSP, NC02_52266gpSP, NC02_52267gpSP, NC02_52269gpSP, NC02_52272gpSP, NC02_52273gpSP, NC02_52274gpSP, NC02_52275gpSP, NC02_52277gpSP, NC02_52278gpSP, NC02_52279gpSP, NC02_52548gpSP, NC02_52549gpSP, NC02_52551gpSP, NC02_52553gpSP, NC02_52554gpSP, NC02_52555gpSP, NC02_52556gpSP, NC02_52557gpSP, NC02_52558gpSP, NC02_52559gpSP, NC02_52560gpSP, NC02_52563gpSP, NC02_52567gpSP, NC02_52570gpSP, NC02_52571gpSP, NC02_52572gpSP, NC02_52573gpSP, NC02_52574gpSP, NC02_52576gpSP, NC02_52577gpSP, NC02_52581gpSP, NC02_52582gpSP, NC02_52589gpSP, NC02_52590gpSP, NC02_52593gpSP, NC02_52595gpSP, NC02_52608gpSP, NC02_52609gpSP, NC02_52610gpSP, NC02_52611gpSP, NC02_52612gpSP, NC02_52613gpSP, NC02_52614gpSP, NC02_52616gpSP, NC02_52624gpSP, NC02_52626gpSP, NC02_52627gpSP, NC02_52628gpSP, NC02_52630gpSP, NC02_54689gpSP, NC02_54732gpSP, NC02_54738gpSP, NC02_54889gpSP, NC02_54891gpSP, NC02_54892gpSP, NC02_54893gpSP, NC02_54894gpSP, NC02_54895gpSP, NC02_54896gpSP, NC02_54897gpSP, NC02_54899gpSP, NC02_54900gpSP, NC02_54901gpSP, NC02_54903gpSP, NC02_54904gpSP, NC02_54908gpSP, NC02_54909gpSP, NC02_54911gpSP, NC02_54915gpSP, NC02_54919gpSP, NC02_54920gpSP, NC02_54921gpSP, NC02_54928gpSP, NC02_54931gpSP, NC02_54932gpSP, NC02_54933gpSP, NC02_54935gpSP, NC02_54936gpSP, NC02_54940gpSP, NC02_54942gpSP, NC02_54944gpSP, NC02_54948gpSP, NC02_54949gpSP, NC02_54951gpSP, NC02_54953gpSP, NC02_54956gpSP, NC02_54957gpSP, NC02_54959gpSP, NC02_54963gpSP, NC02_54965gpSP, NC02_54967gpSP, NC02_54970gpSP, NC02_54971gpSP, NC02_54975gpSP, NC02_54976gpSP, NC02_54977gpSP, SP
Sequence domains: Alphavirus E2 glycoprotein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.2Å
Relevant EMDB volumes: EMD-26947
Expression systems:
  • Mesocricetus auratus
  • Homo sapiens