› 7v1y

Electron Microscopy
2.82Å resolution

Serine beta-lactamase-like protein LACTB in complex with inhibitor

Released:
DOI: 10.2210/pdb7v1y/pdb
PDB entry 7v1y coloured by chain, front view.
PDB entry 7v1y coloured by chain, side view.
PDB entry 7v1y coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Zhang M, Zhang L, Guo R, Xiao C, Yin J, Zhang S, Yang M
Structure 30 685-696.e5 (2022)
PMID: 35247327
Related structures: EMD-31630

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160672 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine beta-lactamase-like protein LACTB, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 487 amino acids
Theoretical weight: 54.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P83111 (Residues: 63-547; Coverage: 89%)
Gene names: LACTB, MRPL56, UNQ843/PRO1781
Sequence domains: Beta-lactamase
ALA-ALA-B3S Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 3 amino acids
Theoretical weight: 261 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand B3S 4 x B3S

Experiments and Validation Details

Entry percentile scores
Resolution: 2.82Å
Relevant EMDB volumes: EMD-31630
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer.
Cascone et al. (2022)
1 more