Function and Biology

CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex

Source organisms:
Biochemical function: protein binding
Biological process: apoptotic process
Cellular component: Cul4-RING E3 ubiquitin ligase complex

EC 3.2.2.27: Uracil-DNA glycosylase

Reaction catalysed:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil
Systematic name:
Uracil-DNA deoxyribohydrolase (uracil-releasing)
Alternative Name(s):
  • UDG
  • UdgB
  • Uracil DNA glycohydrolase
  • Uracil-DNA N-glycosylase

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

Sequence families

Pfam Protein families (Pfam)
PF03167
Domain description: Uracil DNA glycosylase superfamily
Occurring in:
  1. Uracil-DNA glycosylase
The deposited structure of PDB entry 7v7c contains 2 copies of Pfam domain PF03167 (Uracil DNA glycosylase superfamily) in Uracil-DNA glycosylase. Showing 1 copy in chain D.

PF00522
Domain description: VPR/VPX protein
Occurring in:
  1. Protein Vpr
The deposited structure of PDB entry 7v7c contains 2 copies of Pfam domain PF00522 (VPR/VPX protein) in Protein Vpr. Showing 1 copy in chain C.

PF03178
Domain description: CPSF A subunit region
Occurring in:
  1. DNA damage-binding protein 1
The deposited structure of PDB entry 7v7c contains 2 copies of Pfam domain PF03178 (CPSF A subunit region) in DNA damage-binding protein 1. Showing 1 copy in chain B.

PF10433
Domain description: Mono-functional DNA-alkylating methyl methanesulfonate N-term
Occurring in:
  1. DNA damage-binding protein 1
The deposited structure of PDB entry 7v7c contains 2 copies of Pfam domain PF10433 (Mono-functional DNA-alkylating methyl methanesulfonate N-term) in DNA damage-binding protein 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002043
Domain description: Uracil-DNA glycosylase family 1
Occurring in:
  1. Uracil-DNA glycosylase
IPR000012
Domain description: Retroviral VpR/VpX protein
Occurring in:
  1. Protein Vpr
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. DDB1- and CUL4-associated factor 1
  2. DNA damage-binding protein 1
IPR005122
Domain description: Uracil-DNA glycosylase-like
Occurring in:
  1. Uracil-DNA glycosylase
IPR036895
Domain description: Uracil-DNA glycosylase-like domain superfamily
Occurring in:
  1. Uracil-DNA glycosylase
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. DDB1- and CUL4-associated factor 1
  2. DNA damage-binding protein 1
IPR018085
Domain description: Uracil-DNA glycosylase, active site
Occurring in:
  1. Uracil-DNA glycosylase
IPR004871
Domain description: Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Occurring in:
  1. DNA damage-binding protein 1
IPR018846
Domain description: Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Occurring in:
  1. DNA damage-binding protein 1
IPR006594
Domain description: LIS1 homology motif
Occurring in:
  1. DDB1- and CUL4-associated factor 1
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. DDB1- and CUL4-associated factor 1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. DDB1- and CUL4-associated factor 1
IPR033270
Domain description: VPRBP/DCAF1 family
Occurring in:
  1. DDB1- and CUL4-associated factor 1