› 7v83

Electron Microscopy
2.8Å resolution

Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2

Released:
DOI: 10.2210/pdb7v83/pdb
PDB entry 7v83 coloured by chain, front view.
PDB entry 7v83 coloured by chain, side view.
PDB entry 7v83 coloured by chain, top view.
Source organisms:
Entry authors: Yang TJ, Yu PY, Chang YC, Hsu STD
Related structures: EMD-31788

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100247 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1283 amino acids
Theoretical weight: 142.25 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Green fluorescent protein; Processed angiotensin-converting enzyme 2 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 861 amino acids
Theoretical weight: 98.27 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 1-617; Coverage: 76%)
  • Canonical: A0A059PIQ0 (Residues: 3-238; Coverage: 94%)
Gene names: ACE2, UNQ868/PRO1885, gfp
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 29 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-31788
Expression system: Homo sapiens

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