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V1EG domain of V/A-ATPase from Thermus thermophilus at saturated ATP-gamma-S condition, state1-1

Source organism: Thermus thermophilus HB8
Biochemical function: proton-transporting ATP synthase activity, rotational mechanism
Biological process: proton transmembrane transport
Cellular component: proton-transporting ATP synthase complex

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF22919
Domain description: C-terminal domain of V and A type ATP synthase
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF22919 (C-terminal domain of V and A type ATP synthase) in V-type ATP synthase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF22919 (C-terminal domain of V and A type ATP synthase) in V-type ATP synthase beta chain. Showing 1 copy in chain F.

PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in V-type ATP synthase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in V-type ATP synthase beta chain. Showing 1 copy in chain F.

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in V-type ATP synthase alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in V-type ATP synthase beta chain. Showing 1 copy in chain F.

PF16886
Domain description: ATPsynthase alpha/beta subunit N-term extension
Occurring in:
  1. V-type ATP synthase alpha chain
The deposited structure of PDB entry 7vaw contains 3 copies of Pfam domain PF16886 (ATPsynthase alpha/beta subunit N-term extension) in V-type ATP synthase alpha chain. Showing 1 copy in chain A.

PF01991
Domain description: ATP synthase (E/31 kDa) subunit
Occurring in:
  1. V-type ATP synthase subunit E
The deposited structure of PDB entry 7vaw contains 2 copies of Pfam domain PF01991 (ATP synthase (E/31 kDa) subunit) in V-type ATP synthase subunit E. Showing 1 copy in chain L.

PF16999
Domain description: Vacuolar (H+)-ATPase G subunit
Occurring in:
  1. V-type ATP synthase, subunit (VAPC-THERM)
The deposited structure of PDB entry 7vaw contains 2 copies of Pfam domain PF16999 (Vacuolar (H+)-ATPase G subunit) in V-type ATP synthase, subunit (VAPC-THERM). Showing 1 copy in chain I.

PF01990
Domain description: ATP synthase (F/14-kDa) subunit
Occurring in:
  1. V-type ATP synthase subunit F
The deposited structure of PDB entry 7vaw contains 1 copy of Pfam domain PF01990 (ATP synthase (F/14-kDa) subunit) in V-type ATP synthase subunit F. Showing 1 copy in chain H.

PF01813
Domain description: ATP synthase subunit D
Occurring in:
  1. V-type ATP synthase subunit D
The deposited structure of PDB entry 7vaw contains 1 copy of Pfam domain PF01813 (ATP synthase subunit D ) in V-type ATP synthase subunit D. Showing 1 copy in chain G.

InterPro InterPro annotations
IPR022879
Domain description: V-type ATP synthase regulatory subunit B/beta
Occurring in:
  1. V-type ATP synthase beta chain
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. V-type ATP synthase alpha chain
  2. V-type ATP synthase beta chain
IPR022878
Domain description: V-type ATP synthase catalytic alpha chain
Occurring in:
  1. V-type ATP synthase alpha chain
IPR002842
Domain description: V-type ATPase subunit E
Occurring in:
  1. V-type ATP synthase subunit E
IPR002699
Domain description: ATPase, V1 complex, subunit D
Occurring in:
  1. V-type ATP synthase subunit D
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. V-type ATP synthase alpha chain
IPR031686
Domain description: ATPsynthase alpha/beta subunit, N-terminal extension
Occurring in:
  1. V-type ATP synthase alpha chain
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. V-type ATP synthase alpha chain
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. V-type ATP synthase alpha chain
IPR038495
Domain description: V-type ATPase subunit E, C-terminal domain superfamily
Occurring in:
  1. V-type ATP synthase subunit E
IPR036906
Domain description: ATPase, V1 complex, subunit F superfamily
Occurring in:
  1. V-type ATP synthase subunit F
IPR022944
Domain description: ATPase, V1 complex, subunit F, bacterial/archaeal
Occurring in:
  1. V-type ATP synthase subunit F
IPR008218
Domain description: ATPase, V1 complex, subunit F
Occurring in:
  1. V-type ATP synthase subunit F

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