7vf5

Electron Microscopy
3Å resolution

Human m6A-METTL associated complex (WTAP, VIRMA, and HAKAI)

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human m6A writer complexes.
OpenAccess logo Cell Res 32 982-994 (2022)
PMID: 36167981
Related structures: EMD-31947

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-556590 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein virilizer homolog Chain: A
Molecule details ›
Chain: A
Length: 1812 amino acids
Theoretical weight: 202.24 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q69YN4 (Residues: 1-1812; Coverage: 100%)
Gene names: KIAA1429, MSTP054, VIRMA
Sequence domains: Virilizer, N-terminal
Pre-mRNA-splicing regulator WTAP Chains: C, D
Molecule details ›
Chains: C, D
Length: 396 amino acids
Theoretical weight: 44.29 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15007 (Residues: 1-396; Coverage: 100%)
Gene names: KIAA0105, WTAP
Sequence domains: WTAP/Mum2p family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-31947
Expression system: Trichoplusia ni