7vfu

Electron Microscopy
3Å resolution

Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide

Released:
Source organisms:
Related structures: EMD-31959

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-138694 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Voltage-dependent N-type calcium channel subunit alpha-1B Chain: A
Molecule details ›
Chain: A
Length: 2339 amino acids
Theoretical weight: 262.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q00975 (Residues: 1-2339; Coverage: 100%)
Gene names: CACH5, CACNA1B, CACNL1A5
Sequence domains:
Omega-conotoxin MVIIA Chain: E
Molecule details ›
Chain: E
Length: 25 amino acids
Theoretical weight: 2.65 KDa
Source organism: Conus magus
Expression system: Not provided
UniProt:
  • Canonical: P05484 (Residues: 46-70; Coverage: 51%)
Sequence domains: Conotoxin
Voltage-dependent L-type calcium channel subunit beta-1 Chain: D
Molecule details ›
Chain: D
Length: 598 amino acids
Theoretical weight: 65.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02641 (Residues: 1-598; Coverage: 100%)
Gene names: CACNB1, CACNLB1
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: B
Molecule details ›
Chain: B
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-31959
Expression systems:
  • Homo sapiens
  • Not provided