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Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50B in the auto-inhibited E2P state

Source organism: Homo sapiens
Biochemical function: aminophospholipid flippase activity
Biological process: aminophospholipid translocation
Cellular component: phospholipid-translocating ATPase complex

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EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF16212
Domain description: Phospholipid-translocating P-type ATPase C-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 7vgh contains 1 copy of Pfam domain PF16212 (Phospholipid-translocating P-type ATPase C-terminal) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain B.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 7vgh contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain B.

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 7vgh contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain B.

PF16209
Domain description: Phospholipid-translocating ATPase N-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 7vgh contains 1 copy of Pfam domain PF16209 (Phospholipid-translocating ATPase N-terminal) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain B.

PF03381
Domain description: LEM3 (ligand-effect modulator 3) family / CDC50 family
Occurring in:
  1. Cell cycle control protein 50B
The deposited structure of PDB entry 7vgh contains 1 copy of Pfam domain PF03381 (LEM3 (ligand-effect modulator 3) family / CDC50 family) in Cell cycle control protein 50B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005045
Domain description: CDC50/LEM3 family
Occurring in:
  1. Cell cycle control protein 50B
IPR023299
Domain description: P-type ATPase, cytoplasmic domain N
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR032630
Domain description: P-type ATPase, C-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR001757
Domain description: P-type ATPase
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR018303
Domain description: P-type ATPase, phosphorylation site
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR044492
Domain description: P-type ATPase, haloacid dehalogenase domain
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR008250
Domain description: P-type ATPase, A domain superfamily
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR006539
Domain description: P-type ATPase, subfamily IV
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR023298
Domain description: P-type ATPase, transmembrane domain superfamily
Occurring in:
  1. Phospholipid-transporting ATPase IC
IPR032631
Domain description: P-type ATPase, N-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC

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