› 7vo6

X-ray diffraction
1.71Å resolution

High resolution crystal structure of human PSMD10 (Gankyrin)

Released:
DOI: 10.2210/pdb7vo6/pdb
PDB entry 7vo6 coloured by chain, front view.
PDB entry 7vo6 coloured by chain, side view.
PDB entry 7vo6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A crystal form of PSMD10 Gankyrin with channels accessible to small molecules.
Sudharsan MGM, Venkatraman P
Curr. Sci. 122 674-681 (2022)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-522206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
26S proteasome non-ATPase regulatory subunit 10 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75832 (Residues: 1-226; Coverage: 100%)
Gene name: PSMD10
Sequence domains: Ankyrin repeats (3 copies)

Ligands and Environments

1 bound ligand:
Ligand MLA 1 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: P3221
Unit cell:
a: 60.085Å b: 60.085Å c: 122.377Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.196 0.231
Expression system: Escherichia coli

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