› 7vpi

Electron Microscopy
3.6Å resolution

Cryo-EM structure of the human ATP13A2 (E1-ATP state)

Released:
DOI: 10.2210/pdb7vpi/pdb
PDB entry 7vpi coloured by chain, front view.
PDB entry 7vpi coloured by chain, side view.
PDB entry 7vpi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Tomita A, Daiho T, Kusakizako T, Yamashita K, Ogasawara S, Murata T, Nishizawa T, Nureki O
Mol Cell 81 4799-4809.e5 (2021)
PMID: 34798056
Related structures: EMD-32066

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyamine-transporting ATPase 13A2 Chain: A
Molecule details ›
Chain: A
Length: 1184 amino acids
Theoretical weight: 129.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NQ11 (Residues: 1-1180; Coverage: 100%)
Gene names: ATP13A2, PARK9
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ACP 1 x ACP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-32066
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.
Ray et al. (2023)
11 other articles

1 mention without citation

Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Tomita et al. (2021)