› 7vqq

Electron Microscopy
2.9Å resolution

Cryo-EM structure of amyloid fibril formed by FUS low complexity domain

Released:
DOI: 10.2210/pdb7vqq/pdb
PDB entry 7vqq coloured by chain, front view.
PDB entry 7vqq coloured by chain, side view.
PDB entry 7vqq coloured by chain, top view.
Source organism: Aequorea victoria
Primary publication:
Molecular structure of an amyloid fibril formed by FUS low-complexity domain.
Sun Y, Zhang S, Hu J, Tao Y, Xia W, Gu J, Li Y, Cao Q, Li D, Liu C
OpenAccess logo iScience 25 103701 (2022)
PMID: 35036880
Related structures: EMD-32092

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein FUS Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 483 amino acids
Theoretical weight: 51.95 KDa
Source organism: Aequorea victoria
Expression system: Escherichia coli
UniProt:
  • Canonical: P35637 (Residues: 2-214; Coverage: 41%)
Gene names: FUS, TLS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-32092
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Conformational fluctuations and phases in fused in sarcoma (FUS) low-complexity domain.
Thirumalai et al. (2024)
5 other articles

4 mentions without citation

A Comprehensive Analysis of the Intrinsic Visible Fluorescence Emitted by Peptide/Protein Amyloid-like Assemblies.
Balasco et al. (2023)
3 more