› 7vr7

Electron Microscopy
3.49Å resolution

Inward-facing structure of human EAAT2 in the WAY213613-bound state

Released:
DOI: 10.2210/pdb7vr7/pdb
PDB entry 7vr7 coloured by chain, front view.
PDB entry 7vr7 coloured by chain, side view.
PDB entry 7vr7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
OpenAccess logo Nat Commun 13 4714 (2022)
PMID: 35953475
Related structures: EMD-32097

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-545294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Excitatory amino acid transporter 2 Chain: A
Molecule details ›
Chain: A
Length: 581 amino acids
Theoretical weight: 63.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43004 (Residues: 1-574; Coverage: 100%)
Gene names: EAAT2, GLT1, SLC1A2
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

4 bound ligands:
Ligand GJ0 1 x GJ0
Ligand 9Z9 1 x 9Z9
Ligand CLR 2 x CLR
Ligand PC1 2 x PC1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-32097
Expression system: Homo sapiens

Quick links

Citations

2 review citations

A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases.
Fontana et al. (2023)
1 more

1 mention without citation

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini et al. (2022)