› 7vsl

X-ray diffraction
2.5Å resolution

Crystal structure of PDE8A catalytic domain in complex with 10

Released:
DOI: 10.2210/pdb7vsl/pdb
Model geometry
Fit model/data
PDB entry 7vsl coloured by chain, front view.
PDB entry 7vsl coloured by chain, side view.
PDB entry 7vsl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wu X-N, Zhou Q, Huang Y-D, Li Z, Wu Y, Luo H-B

Function and Biology Details

Reaction catalysed: 
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Chain: A
Molecule details ›
Chain: A
Length: 338 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60658 (Residues: 482-819; Coverage: 41%)
Gene name: PDE8A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand 7XI 1 x 7XI
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: OXFORD DIFFRACTION NOVA
Spacegroup: C2221
Unit cell:
a: 76.089Å b: 131.662Å c: 101.507Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.259
Expression system: Escherichia coli BL21

Quick links