7vuz

Electron Microscopy
2.89Å resolution

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2

Released:
Source organism: Homo sapiens
Related structures: EMD-32132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-225724 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Mas-related G-protein coupled receptor member X2 Chain: R
Molecule details ›
Chain: R
Length: 330 amino acids
Theoretical weight: 37.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
scFv Chain: S

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-32132
Expression system: Spodoptera frugiperda