7vv0

Electron Microscopy
3.5Å resolution

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local

Released:
Source organism: Homo sapiens
Related structures: EMD-32133

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152887 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proadrenomedullin N-20 terminal peptide Chain: L
Molecule details ›
Chain: L
Length: 12 amino acids
Theoretical weight: 1.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P35318 (Residues: 30-41; Coverage: 7%)
Gene names: ADM, AM
Mas-related G-protein coupled receptor member X2 Chain: R
Molecule details ›
Chain: R
Length: 330 amino acids
Theoretical weight: 37.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96LB1 (Residues: 1-330; Coverage: 100%)
Gene names: MRGPRX2, MRGX2
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-32133
Expression systems:
  • Not provided
  • Spodoptera frugiperda